diff --git a/pkgs/development/python-modules/libtmux/default.nix b/pkgs/development/python-modules/libtmux/default.nix
index f27a5ac6e221..9382ccd36b63 100644
--- a/pkgs/development/python-modules/libtmux/default.nix
+++ b/pkgs/development/python-modules/libtmux/default.nix
@@ -1,6 +1,7 @@
 { lib
 , stdenv
 , fetchFromGitHub
+, fetchpatch
 , buildPythonPackage
 , poetry-core
 , pytest-rerunfailures
@@ -22,6 +23,15 @@ buildPythonPackage rec {
     hash = "sha256-tz7Pynm/xHx2X3QjXkvFlX6sVlsVKqrsS1CVmqlqfj0=";
   };
 
+  patches = [
+    # https://github.com/tmux-python/libtmux/pull/493
+    (fetchpatch {
+      name = "remove-setuptools.patch";
+      url = "https://github.com/tmux-python/libtmux/commit/aa3a1e2015ade73129191ad04146ce52765d478c.patch";
+      hash = "sha256-p3KMktd6eG9/lRK+DdBvDtSwhI+sV2RQfBAuElMk8tQ=";
+    })
+  ];
+
   postPatch = ''
     sed -i '/addopts/d' setup.cfg
   '';