diff --git a/pkgs/development/python-modules/dnspython/default.nix b/pkgs/development/python-modules/dnspython/default.nix
index ad58f310636c..5676d270935f 100644
--- a/pkgs/development/python-modules/dnspython/default.nix
+++ b/pkgs/development/python-modules/dnspython/default.nix
@@ -30,6 +30,14 @@ buildPythonPackage rec {
     "test_misc_good_WKS_text"
     # fails if IPv6 isn't available
     "test_resolver_override"
+
+  # Tests that run inconsistently on darwin systems
+  ] ++ lib.optionals stdenv.isDarwin [
+    # 9 tests fail with: BlockingIOError: [Errno 35] Resource temporarily unavailable
+    "testQueryUDP"
+    # 6 tests fail with: dns.resolver.LifetimeTimeout: The resolution lifetime expired after ...
+    "testResolveCacheHit"
+    "testResolveTCP"
   ];
 
   nativeBuildInputs = [