diff --git a/nixos/modules/services/desktops/gnome/gnome-remote-desktop.nix b/nixos/modules/services/desktops/gnome/gnome-remote-desktop.nix
index b5573d2fc21b..85b565e8c9e3 100644
--- a/nixos/modules/services/desktops/gnome/gnome-remote-desktop.nix
+++ b/nixos/modules/services/desktops/gnome/gnome-remote-desktop.nix
@@ -28,5 +28,6 @@ with lib;
     services.pipewire.enable = true;
 
     systemd.packages = [ pkgs.gnome.gnome-remote-desktop ];
+    systemd.tmpfiles.packages = [ pkgs.gnome.gnome-remote-desktop ];
   };
 }
diff --git a/pkgs/desktops/gnome/core/gnome-remote-desktop/default.nix b/pkgs/desktops/gnome/core/gnome-remote-desktop/default.nix
index 58fbbc0cfc1f..f23560a18f85 100644
--- a/pkgs/desktops/gnome/core/gnome-remote-desktop/default.nix
+++ b/pkgs/desktops/gnome/core/gnome-remote-desktop/default.nix
@@ -1,4 +1,5 @@
-{ lib, stdenv
+{ stdenv
+, lib
 , fetchurl
 , cairo
 , meson
@@ -16,22 +17,24 @@
 , systemd
 , libsecret
 , libnotify
+, libopus
 , libxkbcommon
 , gdk-pixbuf
-, freerdp
+, freerdp3
 , fdk_aac
 , tpm2-tss
 , fuse3
 , gnome
+, polkit
 }:
 
 stdenv.mkDerivation rec {
   pname = "gnome-remote-desktop";
-  version = "45.1";
+  version = "46.0";
 
   src = fetchurl {
     url = "mirror://gnome/sources/${pname}/${lib.versions.major version}/${pname}-${version}.tar.xz";
-    hash = "sha256-3NnBisIwZpVjH88AqIZFw443DroFxp3zn1QCBNTq/Y0=";
+    hash = "sha256-51zhfBKm05JU3DCcMVFOXvFXY/E2YS1kHF9vREXgCsQ=";
   };
 
   nativeBuildInputs = [
@@ -45,7 +48,7 @@ stdenv.mkDerivation rec {
 
   buildInputs = [
     cairo
-    freerdp
+    freerdp3
     fdk_aac
     tpm2-tss
     fuse3
@@ -56,15 +59,23 @@ stdenv.mkDerivation rec {
     libdrm
     nv-codec-headers-11
     libnotify
+    libopus
     libsecret
     libxkbcommon
     pipewire
     systemd
+    polkit # For polkit-gobject
   ];
 
   mesonFlags = [
+    "-Dconf_dir=/etc/gnome-remote-desktop"
     "-Dsystemd_user_unit_dir=${placeholder "out"}/lib/systemd/user"
+    "-Dsystemd_system_unit_dir=${placeholder "out"}/lib/systemd/system"
+    "-Dsystemd_sysusers_dir=${placeholder "out"}/lib/sysusers.d"
+    "-Dsystemd_tmpfiles_dir=${placeholder "out"}/lib/tmpfiles.d"
     "-Dtests=false" # Too deep of a rabbit hole.
+    # TODO: investigate who should be fixed here.
+    "-Dc_args=-I${freerdp3}/include/winpr3"
   ];
 
   passthru = {