diff --git a/pkgs/development/python-modules/krb5/default.nix b/pkgs/development/python-modules/krb5/default.nix
index ee520b0f0012..f64b73447ac0 100644
--- a/pkgs/development/python-modules/krb5/default.nix
+++ b/pkgs/development/python-modules/krb5/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   cython,
   fetchPypi,
@@ -42,5 +43,6 @@ buildPythonPackage rec {
     homepage = "https://github.com/jborean93/pykrb5";
     license = licenses.mit;
     maintainers = teams.deshaw.members;
+    broken = stdenv.isDarwin; # TODO: figure out how to build on Darwin
   };
 }
diff --git a/pkgs/development/python-modules/requests-kerberos/default.nix b/pkgs/development/python-modules/requests-kerberos/default.nix
index 210e792cfbf7..ffa706fcd58b 100644
--- a/pkgs/development/python-modules/requests-kerberos/default.nix
+++ b/pkgs/development/python-modules/requests-kerberos/default.nix
@@ -1,5 +1,6 @@
 {
   lib,
+  stdenv,
   buildPythonPackage,
   cryptography,
   fetchFromGitHub,
@@ -24,11 +25,14 @@ buildPythonPackage rec {
     hash = "sha256-s1Q3zqKPSuTkiFExr+axai9Eta1xjw/cip8xzfDGR88=";
   };
 
-  propagatedBuildInputs = [
-    cryptography
-    requests
-    pyspnego
-  ] ++ pyspnego.optional-dependencies.kerberos;
+  propagatedBuildInputs =
+    [
+      cryptography
+      requests
+      pyspnego
+    ]
+    # Avoid broken Python krb5 package on Darwin
+    ++ lib.optionals (!stdenv.isDarwin) pyspnego.optional-dependencies.kerberos;
 
   nativeCheckInputs = [
     pytestCheckHook