diff --git a/pkgs/by-name/me/meson/package.nix b/pkgs/by-name/me/meson/package.nix
index ea9e4e002d69..9ac84af31d3d 100644
--- a/pkgs/by-name/me/meson/package.nix
+++ b/pkgs/by-name/me/meson/package.nix
@@ -10,6 +10,7 @@
   pkg-config,
   python3,
   replaceVars,
+  writeShellScriptBin,
   zlib,
 }:
 
@@ -66,12 +67,34 @@ python3.pkgs.buildPythonApplication rec {
     ./007-freebsd-pkgconfig-path.patch
   ];
 
+  postPatch =
+    if python3.isPyPy then
+      ''
+        substituteInPlace mesonbuild/modules/python.py \
+          --replace-fail "PythonExternalProgram('python3', mesonlib.python_command)" \
+                         "PythonExternalProgram('${python3.meta.mainProgram}', mesonlib.python_command)"
+        substituteInPlace mesonbuild/modules/python3.py \
+          --replace-fail "state.environment.lookup_binary_entry(mesonlib.MachineChoice.HOST, 'python3')" \
+                         "state.environment.lookup_binary_entry(mesonlib.MachineChoice.HOST, '${python3.meta.mainProgram}')"
+        substituteInPlace "test cases"/*/*/*.py "test cases"/*/*/*/*.py \
+          --replace-quiet '#!/usr/bin/env python3' '#!/usr/bin/env pypy3' \
+          --replace-quiet '#! /usr/bin/env python3' '#!/usr/bin/env pypy3'
+        chmod +x "test cases"/*/*/*.py "test cases"/*/*/*/*.py
+      ''
+    else
+      null;
+
   nativeBuildInputs = [ installShellFiles ];
 
-  nativeCheckInputs = [
-    ninja
-    pkg-config
-  ];
+  nativeCheckInputs =
+    [
+      ninja
+      pkg-config
+    ]
+    ++ lib.optionals python3.isPyPy [
+      # Several tests hardcode python3.
+      (writeShellScriptBin "python3" ''exec pypy3 "$@"'')
+    ];
 
   checkInputs =
     [
@@ -116,9 +139,15 @@ python3.pkgs.buildPythonApplication rec {
         # pch doesn't work quite right on FreeBSD, I think
         ''test cases/common/13 pch''
       ]
+      ++ lib.optionals python3.isPyPy [
+        # fails for unknown reason
+        ''test cases/python/4 custom target depends extmodule''
+      ]
     ))
     ++ [
-      ''HOME="$TMPDIR" python ./run_project_tests.py''
+      ''HOME="$TMPDIR" ${
+        if python3.isPyPy then python3.interpreter else "python"
+      } ./run_project_tests.py''
       "runHook postCheck"
     ]
   );