diff --git a/pkgs/development/python-modules/sqlalchemy/default.nix b/pkgs/development/python-modules/sqlalchemy/default.nix
index 25e5b0006619..4b13f996e954 100644
--- a/pkgs/development/python-modules/sqlalchemy/default.nix
+++ b/pkgs/development/python-modules/sqlalchemy/default.nix
@@ -1,39 +1,134 @@
 { stdenv
 , lib
+, isPyPy
+, pythonOlder
 , fetchPypi
 , buildPythonPackage
-, isPy3k
-, pythonOlder
+
+# build
+, cython
+
+# propagates
 , greenlet
 , importlib-metadata
+, typing-extensions
+
+# optionals
+, aiosqlite
+, asyncmy
+, asyncpg
+, cx_oracle
+, mariadb
+, mypy
+, mysql-connector
+, mysqlclient
+# TODO: oracledb
+, pg8000
+, psycopg
+, psycopg2
+, psycopg2cffi
+# TODO: pymssql
+, pymysql
+, pyodbc
+# TODO: sqlcipher3
+
+# tests
 , mock
-, pysqlite ? null
 , pytestCheckHook
 }:
 
 buildPythonPackage rec {
   pname = "SQLAlchemy";
-  version = "1.4.40";
+  version = "1.4.41";
+  disabled = pythonOlder "3.7";
 
   src = fetchPypi {
     inherit pname version;
-    hash = "sha256-RKZgUGCAzJdeHfpXdv5fYxXdxiane1C/Du4YsDieomU=";
+    hash = "sha256-ApL3DReX48VOhi5vMK5HQBRki8nHI+FKL9pzCtsKl5E=";
   };
 
+  nativeBuildInputs = lib.optionals (!isPyPy) [
+    cython
+  ];
+
   propagatedBuildInputs = [
     greenlet
+    typing-extensions
   ] ++ lib.optionals (pythonOlder "3.8") [
     importlib-metadata
   ];
 
+  passthru.optional-dependencies = rec {
+    asyncio = [
+      greenlet
+    ];
+    mypy = [
+      #mypy
+    ];
+    mssql = [
+      pyodbc
+    ];
+    mssql_pymysql = [
+      # TODO: pymssql
+    ];
+    mssql_pyodbc = [
+      pyodbc
+    ];
+    mysql = [
+      mysqlclient
+    ];
+    mysql_connector = [
+      mysql-connector
+    ];
+    mariadb_connector = [
+      mariadb
+    ];
+    oracle = [
+      cx_oracle
+    ];
+    oracle_oracledb = [
+      # TODO: oracledb
+    ];
+    postgresql = [
+      psycopg2
+    ];
+    postgresql_pg8000 = [
+      pg8000
+    ];
+    postgresql_asyncpg = [
+      asyncpg
+    ] ++ asyncio;
+    postgresql_psycopg2binary = [
+      psycopg2
+    ];
+    postgresql_psycopg2cffi = [
+      psycopg2cffi
+    ];
+    postgresql_psycopg = [
+      psycopg
+    ];
+    pymysql = [
+      pymysql
+    ];
+    aiomysql = [
+      aiomysql
+    ] ++ asyncio;
+    asyncmy = [
+      asyncmy
+    ] ++ asyncio;
+    aiosqlite = [
+      aiosqlite
+      typing-extensions
+    ] ++ asyncio;
+    sqlcipher = [
+      # TODO: sqlcipher3
+    ];
+  };
+
   checkInputs = [
     pytestCheckHook
     mock
-  ] ++ lib.optional (!isPy3k) pysqlite;
-
-  postInstall = ''
-    sed -e 's:--max-worker-restart=5::g' -i setup.cfg
-  '';
+  ];
 
   # disable mem-usage tests on mac, has trouble serializing pickle files
   disabledTests = lib.optionals stdenv.isDarwin [
@@ -42,8 +137,9 @@ buildPythonPackage rec {
   ];
 
   meta = with lib; {
+    changelog = "https://github.com/sqlalchemy/sqlalchemy/releases/tag/rel_${builtins.replaceStrings [ "." ] [ "_" ] version}";
+    description = "The Python SQL toolkit and Object Relational Mapper";
     homepage = "http://www.sqlalchemy.org/";
-    description = "A Python SQL toolkit and Object Relational Mapper";
     license = licenses.mit;
   };
 }