diff --git a/nixos/lib/systemd-network-units.nix b/nixos/lib/systemd-network-units.nix
index d15485240bd0..c35309a6d262 100644
--- a/nixos/lib/systemd-network-units.nix
+++ b/nixos/lib/systemd-network-units.nix
@@ -147,7 +147,10 @@ in {
     '' + optionalString (def.ipv6SendRAConfig != { }) ''
       [IPv6SendRA]
       ${attrsToSection def.ipv6SendRAConfig}
-    '' + flip concatMapStrings def.ipv6Prefixes (x: ''
+    '' + flip concatMapStrings def.ipv6PREF64Prefixes (x: ''
+      [IPv6PREF64Prefix]
+      ${attrsToSection x}
+    '') + flip concatMapStrings def.ipv6Prefixes (x: ''
       [IPv6Prefix]
       ${attrsToSection x}
     '') + flip concatMapStrings def.ipv6RoutePrefixes (x: ''
diff --git a/nixos/modules/system/boot/networkd.nix b/nixos/modules/system/boot/networkd.nix
index 79d76a8caa94..761bbe6e03d4 100644
--- a/nixos/modules/system/boot/networkd.nix
+++ b/nixos/modules/system/boot/networkd.nix
@@ -952,6 +952,7 @@ let
           "UseGateway"
           "UseRoutePrefix"
           "Token"
+          "UsePREF64"
         ])
         (assertValueOneOf "UseDNS" boolValues)
         (assertValueOneOf "UseDomains" (boolValues ++ ["route"]))
@@ -962,6 +963,7 @@ let
         (assertValueOneOf "UseMTU" boolValues)
         (assertValueOneOf "UseGateway" boolValues)
         (assertValueOneOf "UseRoutePrefix" boolValues)
+        (assertValueOneOf "UsePREF64" boolValues)
       ];
 
       sectionDHCPServer = checkUnitConfig "DHCPServer" [
@@ -1033,6 +1035,14 @@ let
         (assertValueOneOf "EmitDomains" boolValues)
       ];
 
+      sectionIPv6PREF64Prefix = checkUnitConfigWithLegacyKey "ipv6PREF64PrefixConfig" "IPv6PREF64Prefix" [
+        (assertOnlyFields [
+          "Prefix"
+          "LifetimeSec"
+        ])
+        (assertInt "LifetimeSec")
+      ];
+
       sectionIPv6Prefix = checkUnitConfigWithLegacyKey "ipv6PrefixConfig" "IPv6Prefix" [
         (assertOnlyFields [
           "AddressAutoconfiguration"
@@ -2013,6 +2023,16 @@ let
       '';
     };
 
+    ipv6PREF64Prefixes = mkOption {
+      default = [];
+      example = [ { Prefix = "64:ff9b::/96"; } ];
+      type = types.listOf (mkSubsectionType "ipv6PREF64PrefixConfig" check.network.sectionIPv6PREF64Prefix);
+      description = ''
+        A list of IPv6PREF64Prefix sections to be added to the unit. See
+        {manpage}`systemd.network(5)` for details.
+      '';
+    };
+
     dhcpServerStaticLeases = mkOption {
       default = [];
       example = [ { MACAddress = "65:43:4a:5b:d8:5f"; Address = "192.168.1.42"; } ];